Tuesday, November 14, 2006


  • Baroreceptors located in the Aortic Arch and Carotid pathway monitor mean arterial pressure.
  • Short term regulations are mediated by the autonomic nervous system.
  • The blood pressure is monitored by the barorecptors, while the regulation is controlled by the vasomotor centre in the medulla, which regulates sympathetic or parasympathetic responses according the a rise or fall in blood pressure
  • A drop in blood pressure is observed by the baroreceptor and this leads to increase in sympathetic tone and decrease in parasympathetic tone. While a rise in blood pressure leads to an increase in parasympathetic tone and decrease in sympathetic tone.
  • An increase in sympathetic tone gives rise to a rise in peripheral vascular resistance, venous tone, heart rate and contractility of the myocardium.
  • Long term regulations are regulated by humoral factors that regulate blood volume by Sodium and water retention.
  • Renin secretion is directly affected by the changes in renal blood flow and pressure, which in turn directly affects mean arterial pressure.
  • A drop in renal bloodflow or pressure leads to an increase in renin secretion.
  • Increase in renin secretion can also be stimulated by an increase in sympathetic outflow.
  • Increase in renin circulation leads to an increase in angiotensin II produced.
  • Angiotensin II vasoconstriction effects and can directly raise blood pressure.
  • Angiotensin II stimulates the secretion of aldosterone which acts on the kidney to retain Sodium and water, which leads to an increase in blood volume.
  • Beta Adrenegic receptors in the heart respond to norepinephrine and epinephrine which are neurotransmitters released to regulate the sympathetic nervous system.
  • Muscarinic cholinergic receptors bind to Acetylcholine a neurotransmitter which is released by the parasympathetic nervous system.

This is my bpharm practical... yawn im so bored.... here jeremy..

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